Metabolic Inflammation and Insulin Resistance in Obesity
نویسندگان
چکیده
منابع مشابه
Obesity-Induced Inflammation and Insulin Resistance
Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease, and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the i...
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Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance, obesity, and diabetes, we have identified bacterial lipopolysaccharide (LPS) as a triggering factor. We found that normal endotoxemia increased or decreased during the fed or fasted state, respectively, on ...
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There has been a remarkable increase in interest during the past two decades in the relation between cardiovascular risk factors in children and the development of arteriosclerotic cardiovascular disease (ASCVD) and type 2 diabetes in adulthood. Initial studies concentrated on individual factors such as lipids and blood pressure. However, as research in this areahas evolvedandpediatricianshave ...
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Myeloid cells, particularly macrophages, mediate metabolic inflammation, thus promoting insulin resistance and metabolic disease progression in obesity. Numerous cytokines, toxic metabolites, damage-associated molecular patterns, and pathogen-associated molecular patterns are involved in activating macrophages via their cognate receptors in obesity. TRAF3 (TNF receptor-associated factor 3) is a...
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Introduction Obesity is becoming a global epidemic, increasing the health burden of associated complications of insulin resistance and diseases such as cardiovascular disease (1). Because insulin resistance leads to type 2 diabetes (T2D) (2), T2D incidence and prevalence are also increasing rapidly. The number of adults with diagnosed diabetes in the United States nearly quadrupled over 32 year...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2020
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.119.315896